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Currently, CCS1477 is being evaluated in two Phase I/IIa clinical trials (NCT03568656 and NCT04068597), involving patients with advanced solid tumors and hematologic malignancies, including NSCLC characterized by constitutive NRF2 activation

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Ketone bodies have been shown to be more oxygen-efficient compared to fatty acids and may serve as a compensatory fuel in the setting of impaired mitochondrial function

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