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Thus, interference with GSH synthesis in FoB induced an increase in mitochondrial mass without concomitant mtDNA replication

Although this is consistent and mechanistically validated across different preclinical models, as reviewed in the Preclinical and clinical applications of NAD + -modulating interventions for mitochondrial homeostasis and health benefits section, the correspondence between NAD + changes and mitochondrial or metabolic alterations is more complex in human studies

A diet rich in animal products, fortified foods, nutritional yeast, and supplements helps maintain adequate B12 levels

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