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Lancet 371 , 20272038 (2008)

It may soften, but the leather never truly lets go

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Because flow-mediated dilation was impaired by whole smoke, gas phase components of smoke, and plain carbon particles, with no single constituent uniquely responsible, we then explored whether the mechanism involved a common irritation response from the airway involving the vagus nerve, Springer said

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Scientists have found that tobacco smoke can impair the brain's ability to repress fear-related memories, leaving smokers less able to deal with fear and anxiety after a traumatic event