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Levodopas long-term efficacy is, on the other hand, compromised by the development of response oscillations and drug-induced dyskinesias in a majority of patients due to the progressive degeneration of dopaminergic neurons and pulsatile administration of levodopa, and these limitations are the main reasons for continued efforts towards improvements of current dopaminergic strategies

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Men and women both experience shifts in their hormone profiles, but outcomes depend on age and health

(PubMed) Callaghan BC, Little AA, Feldman EL, Hughes RA