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The cartilage particles were digested with collagenase type II (0.2% w/v in BM, Worthington Biochemical, Lakewood, NJ, United States) in a 37C shaker overnight

Different mechanisms have been highlighted and SnCs impact a large panel of immune components such as T-cells, macrophages, or Natural Killers (NK) 43,44

B12 is also essential for maintaining normal brain function and contributing to the psychological health of an individual

It has also been shown that HGF stimulates macrophage differentiation in dendritic immune-suppressive cells, thus facilitating the induction of T lymphocyte regulators, associated with a pivotal role in anti-inflammation

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