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Omega-3 supplementation in cancer patients reduces inflammatory markers such as IL-6 and C-reactive protein (CRP) and improves inflammation-based prognostic scores ( 3.3.2 Affects cell membrane structure and signaling Omega-3 fatty acids can be incorporated into the phospholipid bilayer of cell membranes, significantly altering the fatty acid composition and biophysical properties of the membranes
JCI Insight 3 , e122146 (2018)
In contrast, CHAC1-driven GSH degradation reduces protein SSG, enhances transferrin receptor (TFRC)mediated iron uptake, and exacerbates ferroptosis, whereas hemoglobin SSG shields reactive cysteine residues from excessive oxidation 127,128
This approach addresses potential challenges such as apoptosis in the center of organoids and enhances the physiological relevance of the model for studying endometrial function
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