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Spano et al

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Because BDNF regulates neuronal growth, synaptic remodeling, and adaptive brain responses, its activity intersects with the synaptogenic pathways studied in connection with Dihexa, which may promote neuronal connectivity through HGF/c-Met signaling networks

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Studies suggest that the VEGF/VEGFR-2 pathway may be particularly relevant, as its activation seems to trigger intracellular signaling cascades that potentially influence endothelial cell migration, proliferation, and survival