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A modified FOXO4-p53 interfering peptide causes p53 nuclear exclusion, which can: Selectively induce apoptosis in senescent cells in vitro and in vivo Neutralize phenotypical and liver chemotoxicity by Doxorubicin Restore fitness, hair density and renal function in fast and naturally aged mice Acknowledgments We thank Felicity Chandler for assistance with IHC experiments, Anne Drabbe and David Brouwer for assistance with in vivo experiments, Yanto Ridwan for assistance with CT and IVIS imaging, Yvette van Loon for genotyping of the mice, Martin Viertler for initial NMR experiments, Boudewijn Burgering for fruitful discussions and Petra de Keizer-Burger for critical reading of the manuscript

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Most of the weight-loss medications right nowWegovy, Zepbound, and otherswork by targeting the GLP-1 pathway

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This surge is attributed to increasing research into acetyl-glutathiones potential therapeutic benefits, including its role in treating chronic diseases and supporting drug efficacy