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Understanding the warburg effect: the metabolic requirements of cell proliferation

Modulation of CYP51A1 The expression and activity of CYP51A1 are tightly regulated through both transcriptional mechanisms and post-translational modifications (PTMs), including ubiquitin-mediated degradation and proteinprotein interactions (PPI) (Fig

The Collateral Damage: Allopregnanolone Allopregnanolone (ALLO) is synthesized in the brain from progesterone via a two-step pathway: Progesterone 5-dihydroprogesterone (via 5-alpha reductase) 5-DHP Allopregnanolone (via 3-HSD) Because 5-AR is the rate-limiting step, inhibiting it blocks ALLO productioneven when progesterone levels are adequate

A novel tetramethylpyrazine derivative orophylactically protects against glutamate-induced excitotoxicity in primary neurons through the blockage of N -methyl- D -aspartate receptor

High Risk There is a distinct contradiction between the historical safety data of DSIP and its current regulatory classification