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NFE2-related transcription factor 2 coordinates antioxidant defense with thyroglobulin production and iodination in the thyroid gland

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In the initial stages of obesity, the uptake of fatty acids and glucose by adipocytes leads to the activation of NOX4, the major isoform of NADPH oxidase found in adipocytes, resulting in the increased production of ROS [57,58,59]

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It is well established that an increased capacity of skeletal muscle to oxidize fatty acids can spare glycogen and delay the onset of fatigue in endurance exercise (16, 17,, 19, 30)