Consistent with its disruptions of mitochondrial respiration reflected in the cells OCR measurements, CB-839, starting at low concentrations of 0.1 to 1 M, also decreased the ATP pool in the HG-3 (P = 0.02) and MEC-1 (P = 0.01) cell lines, as measured using high-performance liquid chromatography ( Figure 2D ).The levels of other nucleotides remained stable at all concentration points
Kremer, A
Biochem Biophys Res Commun 289(4):796800 Seto-Young D, Avtanski D, Varadinova M, Park A, Suwandhi P, Leiser A et al (2011) Differential roles of MAPK-Erk1/2 and MAPK-p38 in insulin or insulin-like growth factor-I (IGF-I) signaling pathways for progesterone production in human ovarian cells
Karimi, G., Vahabzadeh, M., Lari, P., Rashedinia, M., & Moshiri, M
doi: 10.4103/jhrs.JHRS_135_18
236 SIRT2 inhibits the peroxidase activity of peroxiredoxin-1 (Prdx-1) by deacetylation, increasing oxidation, and sensitizing breast tumor cells to further increase ROS