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Acknowledgements We acknowledge Council of Scientific and Industrial Research (CSIR), and Department of Science and Technology, Government of India, New Delhi, India, for providing financial support

Cagrilintide targets multiple mechanisms to reduce appetite and body weight: Delays gastric emptying Promotes satiety via the brains hypothalamus Reduces food cravings and portion size Suppresses glucagon secretion Improves metabolic flexibility Cagrilintides effect is particularly powerful when combined with GLP-1 agonists or lifestyle changes such as reduced-calorie diets, regular exercise, and sleep optimization

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Data availability Raw 16S rRNA bacterial sequence data (fastq files and metadata) is available from NCBI through BioProject Accession number PRJNA1189833

X-ray and solution structures of Cu(II) GHK and Cu(II) DAHK complexes: influence on their redox properties