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Bishop outlined several methodological issues with the 2020 paper in her October 2023 PubPeer post, including unclear ethics approvals, vague and irreplicable descriptions of the tested interventions, and the assessors being privy to whether a participant received the intervention or not

Here, PQQ administration to TAC-operated mice was found to improve cardiac remodeling, dysfunction, and fibrosis, with similar results being confirmed in vitro using PQQ-treated cardiomyocytes that had been exposed to PE to model hypertrophy

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