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Storage conditions that shorten unopened shelf life: heat (extended exposure above 25C), freezing and re-thawing (can crack the stopper seal), direct sunlight (degrades benzyl alcohol), and humid environments (can degrade label readability and obscure exp date)

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Tirzepatide causes gastrointestinal symptoms including nausea, vomiting, diarrhea, and constipation in a substantial percentage of users, particularly during dose escalation phases