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In PD, early GSH depletion in the substantia nigra precedes dopaminergic neuron loss, suggesting that redox dysfunction may be an inciting event that leads to eventual neuronal damage (Smeyne and Smeyne, 2013)

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As the role of lactate in disease progression becomes increasingly evident, strategies aimed at modulating lactate metabolism are receiving growing attention in conditions including neurodegenerative disorders, IRI, sepsis and cancer