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The reactive metabolites generated after drug biotransformation can covalently bind to cellular proteins, lipids, and nucleic acids, leading to triggering immune responses and cellular damage (Fig

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Diabetic kidney disease has been estimated to occur in 2040% of diabetes mellitus patients (Radbill 2008

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Blunted lipolytic response to fasting in abdominally obese women: evidence for involvement of hyposomatotropism