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Hemoglobin S-nitrosation on oxygenation of nitrite/deoxyhemoglobin incubations is attenuated by methemoglobin

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AK, ST and S are grateful to CSIR for SRF and RA, respectively

This unexpected finding may be explained by immune-modulatory mechanisms that reduce vascular inflammation and damage

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228,229 Genetic studies suggest that polymorphisms in the aldose reductase gene influence individual susceptibility to DPN, 230 highlighting the potential for personalized therapies