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While the biochemical potential of berberine and alpha lipoic acid is immense, realizing these benefits in a clinical setting requires navigating significant challenges related to bioavailability and absorption

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Supplementation of cells with zinc obviously reverses this process, while excess zinc triggers oxidative stress and ROS production, which further induces the oxidation of zinc-binding proteins and the release of zinc, forming a positive feedback loop that accelerates cell death [165]

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Cohen's D was used to determine the effect size between the two groups