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Even more, ellagic acid has additionally been shown to increase monoamine oxidase B (MAO-B), nuclear factor (erythrocyte derivation 2), Nrf2, and heme oxygenase 1 (HO-1) and reduce the loss of tyrosine hydroxylase (TH)-positive neurons in the substantia nigra pars compacta (SNC) (Sarkaki et al., 2016)

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Virtually all lung cancers that develop in the context of a germline EGFR mutation harbour a secondary somatic activating mutation in EGFR in cis 193 , most commonly L858R 197,200

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