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Further, because Nox2 is depleted from the entire host in vivo, it is possible that Nox2 deletion from other cell populations within the tumor microenvironment also contributed to tumor suppression

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Antioxid Redox Signal 30:12381268 Winkler BS, Orselli SM, Rex TS (1994) The redox couple between glutathione and ascorbic acid: a chemical and physiological perspective