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K48-linked ubiquitination promotes proteasomal degradation, whereas K63-linked ubiquitination activates NLRP3 by recruiting binding partners, and deubiquitination by enzymes such as BRCA1/BRCA2-containing complex subunit 3 (BRCC3) and ubiquitin-specific protease 1 USP1/UAF1 or BRCC3 reverses this inhibition

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Lancet Oncol 19: e430, 2018

(01:20:50) How to Apply Knowledge & Learning (01:23:44) Roberts New Book: Determined: The Science of Life Without Free Will (01:28:27) Reflections, Support of Podcast, & Supporting Stress Research Title Card Photo Credit: Mike Blabac Disclaimer Day 35 Healthy Eating & Eating Disorders - Anorexia, Bulimia, Binging | Episode 36 In this episode, I discuss what drives hunger and satiety, and the role our brain, stomach, fat and hormones play in regulating hunger and turning off the desire to eat more

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Spontaneous calcium waves in Bergman glia increase with age and hypoxia and may reduce tissue oxygen