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PLGA and other biodegradable carriers can readily be functionalized with GSH-cleavable linkers or redox-sensing moieties, providing clinically tractable routes to translate GSH-responsive designs into precision treatments [23]

These include myocardial I/R injury, diabetic cardiomyopathy (DCM), sepsis-induced cardiac injury, hypertrophic cardiomyopathy, atherosclerotic cardiovascular disease, HF, aortic aneurysm (AA), and hypertension (Figure 7)

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