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Hardie DG, Hawley SA, Scott JW

CV safety is currently under investigation for tirzepatide in patients with obesity without diabetes (NCT05556512) and for cagrilintide/semaglutide with overweight and obesity with and without diabetes (NCT05669755)

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Causes and considerations: Direct taste sensation from the copper-containing complex Post-nasal drip from nasal formulations Transient effect often mitigated with delivery technique adjustments The metallic taste is not typically a clinically meaningful adverse effect, but it can be bothersome enough that patients discontinue therapy