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Methods: Following PRISMA guidelines, comprehensive literature retrieval with PubMed, EMBASE, and the Cochrane Library was conducted to identify studies that directly compared the outcomes of distal versus proximal placement of guide catheter

Research Use Only positioning (not for diagnostic, therapeutic, or clinical applications)

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In cultured human cells exposed to heavy metals (Zn, Co, Ni) known to induce DNA breaks and strand instability, Epitalon significantly reduced the extent of genotoxic damage, acting as a protective agent [36]