The Documentation of Goals of Care Discussions Among Cancer Patients measure is a process measure which would focus on the essential process of documenting goals of care conversations in the EHR by assessing the presence of this documentation in the medical record
it upregulates heme oxygenase-1 (HO-1) and other antioxidant and detoxification genes ( + by reducing the heme-associated ferric iron (Fe + ) to Fe + ( + must then be tightly regulated, either stored within ferritin or exported by FPN, to avoid intracellular accumulation and subsequent ferroptosis ( Hepcidin can induce the internalization and degradation of FPN, thereby reducing cellular iron export and elevating intracellular iron levels ( In addition to these canonical signaling pathways, recent single-cell transcriptomic studies have revealed marked heterogeneity in ferroptosis susceptibility among chondrocyte subpopulations in OA cartilage
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Acknowledgements This work was created as part of NCCR Catalysis, a National Centre of Competence in Research funded by the Swiss National Science Foundation (grant number 180544 to R.M.B) and by AEI (Spain) (grant number RTI2018-099592-B-C22 to G.J.-O)
