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A meta-analysis

Similarly to the results obtained here, earlier works have reported oxidative stress-related NGF up-regulation in peripheral tissues such as heart (Valdovinos-Flores and Gonsebatt, 2013), that could lead to the observed increase in plasma NGF protein levels after treatment with BSO and iAs (Figure 1)

Researching the difference between the two kinds of arbutin, you can read in multiple places on the internet that alpha-arbutin is stronger in effect

& Brubacher, J

Inhibiting NNMT with 5-Amino-1MQ restores NAD+ pools, which activates AMPK (AMP-activated protein kinase), the cellular energy sensor that shifts metabolism from glucose storage to fat oxidation

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