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223,224,225,226 When mitochondrial dysfunction occurs, it often shows a decline in physical function and the occurrence of age-related diseases

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96 Additionally, AMPK activation by reduced ATP levels maintains NADPH through inhibiting NADPH consumption in fatty-acid synthesis and enhancing NADPH production from fatty-acid oxidation instead of PPP to inhibit cell death

Liu J, Li K, Cai J, Zhang M, Zhang X, Xiong X, et al