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The closest low-exposure anchor is ONeil 2018, where daily injections totaling roughly 0.35 mg per week produced measurable weight loss over 52 weeks. That supports low-exposure activity, not a tested weekly microdose protocol

Wang et al, 2014)

Martinez E

While it is known that skin cells can produce estrogens locally, aromatase enzyme activity is dramatically reduced to approximately 30 times lower than in premenopausal ovarian follicular tissue [10]

Covering each is out-of-scope for this article, so well instead highlight just two

Epigallocatechin gallate attenuates fibrosis, oxidative stress, and inflammation in non-alcoholic fatty liver disease rat model through TGF/SMAD, PI3 K/Akt/FoxO1, and NF-kappa B pathways