GPx2 is predominantly found in the gastrointestinal tract, liver, kidney, skin, brain, and other organs and is important for stem cell survival (Kipp 2019)
In WT animals, consistent with previous reports, we observed significant downregulation of key genes associated with SMCs contractility, including Acta2 , Cacna2d1 , Cnn1 , Myh6 , Myh11 , Adamts6 , and Mylk, indicating loss of SMC contractility phenotype during AAA development
collagen, vitamin C
Reduced lipogenesis and increased lipolysis in white adipose tissue Research demonstrated that NNMT inhibition by 5-Amino-1MQ reversed diet-induced obesity in mice, with significant reductions in body weight and white adipose tissue mass without affecting food intake
1, Supplementary Table 1)
This is why you cannot simply convert a tirzepatide dose to a retatrutide equivalent