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In addition, NO reacts with superoxide (O 2 ), a major ROS, to produce peroxynitrite (ONOO), a potent oxidant that damages cellular components such as proteins, lipids, and DNA [136138]

After euthanizing the mice on day 12, periwound skin tissue was collected from different groups for follow-up experiments, as detailed in the subsequent section

Human results are not established, and large human trials have not been completed, which is a critical limit to keep in mind

If it separates quickly, it may not be effective anymore

10.3390/medicina58040472 3