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To overcome the problem, prodrugs activated only after oral absorption were developed

Transdermal delivery, favoured for its active and passive approaches and advantages over topical delivery, has been extensively studied and employed for therapeutics

doi: 10.1161/01.HYP.0000035396.27909.40 17 YousifMHMDhaunsiGSMakkiBMQabazardBAAkhtarSBenterIF

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Dual-fluorescence imaging further confirmed its strong in vitro transdermal delivery capacity, providing a solid foundation for subsequent biological evaluations