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People with histamine intolerance usually have several of the symptoms above, but likely wont have all of the symptoms.[ref] Genetics plays a big role in histamine intolerance

A compound that produces identical protective effects whether administered systemically or topically to the target tissue suggests both a circulating effector mechanism and a local tissue-level mechanism, consistent with the dual NO-VEGF angiogenic pathway described above

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10.1016/j.molliq.2024.124566 209

The aromatic amino acids of peptide (tyrosine) form hydrogen bonds with His263, simulating the interaction between phenolic hydroxyl groups of L-tyrosine and His263 (Goldfeder et al., 2014)

Ultra Potent-C 500 may help support healthy immune function and is a good source of antioxidants from vitamin C