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Recent findings have demonstrated that the loss of ApoE function promotes neurodegeneration (Pankiewicz et al., 2021), highlighting the significant role of ApoE in neuronal loss

Adverse Drug React Toxicol Rev 1996 Mar

That is the main practical reason the protocol uses a 4-week climb at each step

The impact of OS triggered by culture media can partially deplete oocyte GSH content, enhancing the effect of sustained OS and thus, risking oocyte fertilization and viability [393]