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Effect of c-Met inhibitor SU11274 on human colon cancer cell growth

A Broad Institute Connectivity Map analysis revealed that GHK-Cu modulates expression of over 4,000 human genes, including many involved in inflammatory pathways

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It undergoes hepatic metabolism to the active metabolite desipramine, which preferentially inhibits norepinephrine reuptake

The peptide's efficacy against high-SASP senescent cells proves particularly valuable in the kidney microenvironment, where inflammatory signaling from senescent tubular cells impairs filtration and promotes fibrosis

Dumont, Larry J 2020