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These phospholipids readily undergo Fe + -dependent lipid peroxidation, creating a pro-ferroptotic microenvironment ( 4-Hydroxynonenal (4-HNE), a characteristic end-product of -6 polyunsaturated fatty acid (e.g., arachidonic acid) lipid peroxidation, serves as a key molecular biomarker of ferroptosis ( Cumulatively, the core mechanism of ferroptosis involves synergistic amplification of lipid peroxidation cascades through multiple feedback loops