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In addition, the combination of Exos with antioxidants, iron chelators, or other therapeutic agents could boost their efficacy

Besides, cAMP, along with IL-4, activates CCAAT/enhancer-binding protein (C/EBP) to induce the expression of M2 regulatory genes (such as arginase-1), thus reducing the expression of M1-related inflammatory factors and increasing the expression of M2-related anti-inflammatory mediators (such as FIZZ1) (117)

Asian Pac J Trop Biomed

Proc Natl Acad Sci U S A 111(29):107616 Chojnacki C et al (2023) Beneficial effect of increased tryptophan intake on its metabolism and mental state of the elderly

doi: 10.1007/978-3-319-55330-6_25 [DOI] [PubMed] [Google Scholar] 39

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