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This syndrome has been reported to be more likely if the patient has abnormal kidney function.9 Although there is some significant debate on this point10, it is generally agreed that patients with abnormal kidney function should start allopurinol at low doses and build up, to ensure that the allopurinol is effectively excreted

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The Ang IV analogue peptide 4 and the Nle-Ang IV analogue 5 provide examples comprising two basic amino groups accessible for protonation in the N-terminal of the peptides and flanking hydrophobic 2-isopropyl and n-butyl side chains, respectively (Figure 2) (Sardinia et al., 1994)

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