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For a detailed overview of this topic, we refer readers to our review articles [128,129,130]

Statements Author contributions GB: Conceptualization, Data curation, Resources, Writing original draft, Writing review & editing

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If symptoms are persistent but manageable: Consider a temporary dose reduction of one step in the escalation schedule

Furthermore, the mitochondria often exhibit a loss of cristae and may show ruptures in their outer membranes (20,27,28)

Inflammation is a defense response of the body to injury or infection, but an excessive inflammatory response can lead to tissue damage and delayed healing