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These reactions are often mechanical or pH-related rather than immune-mediated

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These sound alarming, but they are almost always transient and mild

Subcutaneous injection is the most common research-context format today, but no published human pharmacokinetic study has formally characterized subcutaneous AOD-9604 (this gap was specifically called out in FDA's December 2024 review)

This highlights the intricate and varied processes at play in MET dysregulation's role in controlling PD-L1, suggesting the need for further investigation

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