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The results showed that different linkers did not have a remarkable influence on the in vitro binding affinity of MDM2, while positively charged residues produced a significant enhancement in cell uptake and targeted capability in cellular reporter assay, indicating that positive charge is crucial for achieving cell viability using WT-p53 sequence-based stapled peptides

484 Additionally, hydroxynorketamine (HNK), a metabolite of ketamine, can exert its anti-depressive effects by an NMDAR-independent mechanism

IV therapy should not replace a comprehensive medical evaluation or standard medical care

Biomarkers of oxidative protein damage (3-nitrotyrosine

Furthermore, the loss of neurotrophic support can lead to neurodegeneration and apoptosis, contributing to the cognitive and emotional deficits associated with ethanol-induced depression (Li et al

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