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The copper moiety itself is likely a contributing factor, given coppers established role in collagen synthesis and enzyme activation

The Phase 2 NEJM trial showed 24.2% average body weight reduction at 48 weeks in the 12mg group

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In DMSO-treated control, only few endothelial cells migrated from the upper to the lower chamber through the membrane after 12-hour incubation, when the lower chamber contained culture medium supplemented with 10% FBS as a chemoattractant