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Additional testing may be considered for people with a family history of premature heart disease, metabolic risk, abnormal cholesterol results, known cardiovascular disease, or uncertainty after standard testing: ApoB, Lp(a), and hs-CRP may help reveal particle burden, inherited risk, and inflammation that are not fully captured by LDL cholesterol alone

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This landscape illustrates both the promise and challenges: multiple valid targets exist, but translational failures have been common

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