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In addition, COX-2 is the main trigger of oxidative and inflammatory responses that are often detected in photoaging and other stress/inflammatory disorders (138)

Avoid using harsh or abrasive products, such as exfoliants or astringents, while using tretinoin to prevent further irritation

doi: 10.1186/s13024-022-00566-4 119 Fernndez-CalvetA.Matilla-CuencaL.IzcoM.NavarroS.SerranoM.VenturaS.et al

Lancet 387 , 679690 (2016)

Nelson KJ, Smalley TL Jr, Messier T, Gumpena R, Gandhi U, Milczarek S, et al