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After 48 h, the mice were sacrificed, and the tumors as well as major organs (heart, liver, spleen, lung, kidney) were collected to measure their fluorescence intensity

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In cancer, VEGF is produced and secreted by tumor cells and surrounding stroma and is associated with tumor progression, increased vessel density, invasiveness, metastasis and tumor recurrence [119]

Fair skin tones may notice results sooner (1-3 months), while darker complexions often require 6-12 months for significant brightening