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Preclinical studies demonstrated that AOD-9604 was generally safe after chronic oral application in rats and cynomolgus monkeys, with no genotoxic concerns identified
Current clinical advancement strategies include structural engineering of vitamin K analogs (e.g., C11-alkyl chain-modified MK4-C11) to enhance brain bioavailability and adeno-associated virus (AAV)-mediated FSP1 gene delivery (NCT05543659) to restore vitamin K reduction capacity, driving the transformation of vitamin K from a fundamental nutrient into a clinically viable targeted ferroptosis therapeutic
M., Patel, P., & Mazzoni, T
Supramolecular peptide hydrogel adjuvanted subunit vaccine elicits protective antibody responses against West Nile virus
BL, Bifidobacterium longum NCC3001