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AX further enhances the expression of liver X receptor alpha (LXR) and bile acid synthesis enzymes such as cholesterol 7-hydroxylase (CYP7A1) and cytochrome P450 27A1 (CYP27A1), promoting cholesterol conversion into bile acids and preventing hepatic lipid overload

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An equal volume of dye Mastermix (1 M JC-1, 0.005% digitonin, 10 g ul 1 oligomycin, 5 mM -mercaptoethanol in DTEP buffer) was added, and after 10 min at room temperature, the cells were added on top of the peptide template at a concentration of 40,000 cells per well

Tirzepatide reduces 24-hour ambulatory blood pressure in adults with body mass index 27 kg/m(2): SURMOUNT-1 ambulatory blood pressure monitoring substudy

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