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Second, the gut microbiome influences systemic immune balance

Initial Loading Dose Protocol For severe deficiency, the first dose is usually 1,000 mcg given intramuscularly

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High-dose oral vitamin B12 supplements (1000-2000 micrograms per day) have also been shown to raise levels, because high doses can usually compensate for the bodys poor absorption

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However, most studies have focused on the active ingredients of natural plant compounds, failing to fully harness the complex effects of these compounds