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However, it is crucial to understand that this comparison addresses safety profiles only, not therapeutic equivalence

Evidence boundary The published trial record describes safety more clearly than efficacy

IV doses of 25-400 mcg/kg for safety studies Important: These are experimental doses used in animal studies and cannot be extrapolated to other species due to significant differences in metabolism, pharmacokinetics, receptor expression, peptide degradation rates, and tissue distribution patterns

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W., & Rowe, H

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