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Not for use in food, drug, or cosmetic applications

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Before azathioprine and 6-MP are administered, test all patients for TPMT and NUDT15 activity Patients with normal TPMT and NUDT15 activity may be treated with full-dose azathioprine or 6-MP Methotrexate Parenteral methotrexate at a dose of 25 mg weekly is effective for inducing and maintaining remission in patients with CD