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Changes in serum cytokine concentrations and the relationship between cytokine gene variants and the clinical course of the disease have been described in WD patients, as well as in animal models of this disease

Research suggests that when combined, these two peptides may influence GH regulation through complementary mechanisms

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2012;302:R274282

Similar strategies may also be used to deplete IgA, as explored with the pre-clinical candidate BHV-1400 [434], which leverages ASGPR biology in a manner similar to BHV-1300 and could represent an alternative to the likely mechanism-of-action of ARGX-121, and to deplete IgE, as shown with lysosomal targeting chimeras coupling pH-sensitive target binding and ASGPR-mediated endolysosomal delivery to FcRn-mediated cellular transport of the potential therapeutic molecule [435]

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